Anaphylaxis , angioedema , urticaria , fever, chills, flushing, malaise, dyspnea [ Ref ] Immunologic Frequency not reported: Progression of cataracts, ophthalmoplegia[ Ref ] Psychiatric Frequency not reported: Depression, suicidal thoughts, delusions, paranoia, agitation, decreased libido, anxiety , insomnia , nightmares [ Ref ] Genitourinary Frequency not reported: Erectile dysfunction , impotence , testicular pain[ Ref ] Oncologic Frequency not reported: Tumor growth, liver, thyroid, lung adenomas, carcinomas[ Ref ] References 1. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia. Muscle abnormalities in four patients taking statins to treat unfavorable cholesterol levels.
I45 3. Bilheimer DW "Long-term clinical tolerance of lovastatin and simvastatin. Simons LA "Simvastatin in severe primary hypercholesterolemia: The Principal Investigators. Cerner Multum, Inc. Zocor simvastatin. Grundy SM "Can statins cause chronic low-grade myopathy? Gonyeau MJ "Statins and osteoporosis: Walker JF "Simvastatin: Molden E, Andersson KS "Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem. Available from: Gregoor PJ "Atorvastatin may cause nightmares.
A meta-analysis of large randomized clinical trials. Some side effects may not be reported. Do not take Zocor if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine. See also: Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Zocor. How should I take Zocor? Take Zocor exactly as prescribed. Follow all directions on your prescription label.
Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects. Zocor is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. While using Zocor, you may need frequent blood tests at your doctor's office. You may need to take Zocor on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency.
Do not stop taking this medicine unless your doctor tells you to. Zocor is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Zocor dosage information in more detail What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Zocor?
More about Zocor (Generic) Blink Health reserves the right to change its prescription drug prices in real time based on supply and demand trends and other factors. Any savings claims made by Blink are based on U.S. retail prices without prescription drug coverage. *Retail Prices . HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ZOCOR safely and effectively. See full prescribing information for ZOCOR. ZOCOR(simvastatin) tablets, for oral use Initial U.S. ApprovalRECENT MAJOR CHANGESDosage and Administration. 2/4/ · Take Zocor exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects. Zocor is usually taken at bedtime or with an evening meal.
Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Zocor dosage information in more detail What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Zocor? Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects.
Avoid the use of grapefruit products while taking Zocor. Avoid eating foods that are high in fat or cholesterol. Zocor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Zocor side effects Get emergency medical help if you have any of these signs of an allergic reaction to Zocor: In rare cases, Zocor can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Also call your doctor at once if you have: Common Zocor side effects may include: This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Zocor side effects in more detail What other drugs will affect Zocor? Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Zocor, especially: This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Experience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozil , nicotinic acid, cyclosporin, or erythromycin may increase the incidence and the severity of musculoskeletal side effects.
Patients should be instructed to report symptoms of muscle pain, weakness, or tenderness. If such symptoms develop, creatine kinase should be measured, and if elevated, simvastatin should be discontinued. The value of regular monitoring of creatine kinase is not known. In some studies, elevations in creatine kinase occurred in up to 5. In most cases, these elevations were mild, transient, and not associated with clinical symptoms. In one study, this led to the discontinuation of simvastatin in 0. In other patients, elevations in liver function tests were transient and returned to normal with continued simvastatin therapy. Liver function tests should be closely monitored.
Simvastatin should be discontinued in patients with persistent, significant elevations 3 times normal in liver function parameters. Elevations in liver function tests Frequency not reported: Constipation, nausea, flatulence , diarrhea, dyspepsia , abdominal pain Very rare less than 0. Protein-losing enteropathy Frequency not reported: Anorexia, pancreatitis , vomiting[ Ref ] Hematologic Frequency not reported: Headache Frequency not reported: Cognitive impairment, cranial nerve dysfunction, tremor, vertigo , memory loss , paraesthesias, peripheral neuropathy , peripheral nerve palsy[ Ref ] Renal Frequency not reported: Eczematous, pruritic rash, erythema multiforme, Stevens-Johnson syndrome , toxic epidermal necrolysis , photosensitivity, purpura, alopecia [ Ref ] Endocrine Frequency not reported: Hypospermia, gynecomastia, thyroid function abnormalities, increases in HbA1c and fasting serum glucose levels.
Acid maltase deficiency the genetic disorder also referred to as Pompe's Disease has been revealed following simvastatin the active ingredient contained in Zocor therapy in at least one presymptomatic patient. Anaphylaxis , angioedema , urticaria , fever, chills, flushing, malaise, dyspnea [ Ref ] Immunologic Frequency not reported: Progression of cataracts, ophthalmoplegia[ Ref ] Psychiatric Frequency not reported: Depression, suicidal thoughts, delusions, paranoia, agitation, decreased libido, anxiety , insomnia , nightmares [ Ref ] Genitourinary Frequency not reported:
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