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You should take the drug orally without or with food. It is important that you strictly follow your doctor's prescription. Biaxin is usually recommended to be taken every 12 hours. In case you experience stomach upset while using this medicine, you should take it with a glass of milk or food. Generally, antibiotics are more effective when the level of drug in the body is constant. It is therefore crucial that you take the medication at an evenly spaced period. It might be sometimes hard to remember the timing of the medication.
You should therefore set a reminder to help you remember your dosing time. The duration and dosage of your treatment is usually dependent on your health condition, as well as your response to it. Important to Know Before you start taking this drug, inform your doctor if you have allergic reaction to its active ingredient, Clarithromycin, or to any other macrolide antibiotics, such as Erythromycin, or Azithromycin. There are other inactive ingredients in this medicine that can cause allergies. Consult your doctor to get an exhaustive list of allergies. It is important that you inform your physician about your medical history and let him know if you have any of the following health conditions: Liver disease; Kidney disease; Some certain muscle disease known as myasthenia gravis.
This medication can also cause a health condition that affects heart rhythm known as QT prolongation. This health condition sometimes results in serious irregular or fast heartbeat, or other effects like fainting or severe dizziness. Instructions on Taking The dosage of Biaxin Clarithromycin for children is usually based on their weight. Ensure you complete your dose if you are using the drug for the treatment of an infection even if you experience relief from your symptoms. If you stop your medication halfway, you may develop drug resistant which is not good for your health. Developing tablets resistant means the medicament will not be effective for subsequent treatment.
You should also inform your physician if your symptoms worsen or persist. Biaxin is a prescription drug thus it should only be taken with your doctor's recommendation. If you are using it for the treatment or prevention of certain bacterial infections, you should follow the doses instructions as recommended by your doctor.
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Clarithromycin may act on gastrointestinal motility in a similar way. In dogs, clarithromycin caused contractions and discomfort, as did erythromycin. In healthy volunteers, oral clarithromycin 250 mg bd caused a statistically significant increase in the number of postprandial antral contractions and antral motility. A single oral dose of clarithromycin 3000 mg resulted in severe abdominal pain within 1 hour of administration in two patients. Based on observations made in dogs and rabbits, clarithromycin is significantly less potent than azithromycin and erythromycin as an agonist for stimulation of smooth muscle contraction. Therefore, a lower rate of gastrointestinal adverse events would be expected with clarithromycin.
Pseudomembranous colitis is relatively rarely seen with macrolides, but has been reported with clarithromycin. Clarithromycin was also associated with cholestatic hepatitis. The pattern of liver enzyme abnormality was primarily cholestatic, and the patients were typically elderly all but one aged over 60 years , or of low weight. Only three patients were symptomatic, and the liver function abnormalities resolved on withdrawal. Subsequent rechallenge was successful in four patients, unsuccessful in one, and not performed in four.
There was some dispute as to whether toxicity was dose-related or not, but it is wise to recommend that elderly patients should receive an initial daily dose of 1 g in this disease setting. Although cholestatic hepatitis has been typically described in association with erythromycin, newer macro-lides are not totally free of this risk. A gradual increase in bilirubin and transaminases has been reported during treatment of a Mycobacterium chelonae infection with clarithromycin. These alterations were quickly reversible after withdrawal, but re-appeared on re-exposure to clarithromycin 1 g. Fatal drug-induced cholestasis associated with clarithromycin 500 mg bd for 3 days has been reported in a 59-year-old woman with diabetes mellitus and chronic renal insufficiency.
Idiosyncratic drug-induced fatal fulminant hepatic failure has been reported in a 40-year-old woman with end-stage renal insufficiency taking clarithromycin 500 mg bd. Skin Clarithromycin has been associated with fixed drug eruptions and hypersensitivity reactions. In one case a clarithromycin-induced fixed drug eruption was reproduced by oral provocation, whereas patch tests on both unaffected and residual pigmented skin were negative. A 31-year-old woman developed Stevens-Johnson syndrome after she had taken oral erythromycin 333 mg tds for otitis media.
After two doses she developed oral ulcers, tongue swelling, and a generalized erythematous rash. The diagnosis was confirmed histologically. She recovered slowly after withdrawal of erythromycin. Roxithromycin-induced generalized urticaria and tachycardia with a positive prick test and a cross-reaction to erythromycin and clarithromycin has been reported in a 31-year-old woman. Clarithromycin can cause phototoxicity. Side Effects See also Macrolide antibiotics Clarithromycin is a commonly used macrolide antibiotic and is a regular part of regimens for the eradication of Helicobacter pylori , often in combination with a nitromidazole antibiotic as well, in addition to a proton pump inhibitor.
Comparative studies In a double-blind, multicenter trial in 328 patients with H. The rate of success and quality of life were similar in both groups. There were no serious adverse events. However, there were 12 withdrawals in the group given omeprazole and antibiotics and two in the group given omeprazole alone. Diarrhea occurred in 63 patients in those given omeprazole and antibiotics and in ten patients given omeprazole alone. In another double-blind, placebo-controlled trial eradication of H. Treatment regimens for patients with a positive culture for MAC from a sterile site should include two or more drugs, including clarithromycin.
In a prospective, single-blind, randomized study of a 7-day course of clarithromycin 7. Three subjects given erythromycin withdrew prematurely because of adverse events: Tetracyclines Clarithromycin 0. Eight patients did not complete the study owing to deviations from protocol or adverse effects. Persistently negative cultures were found in 14 of the other patients. There were three cases of hepatic disturbances and three of ototoxicity, which required a reduction in clarithromycin dosage after a short interruption of treatment. I am experiencing the metallic Taste.
How long does this last? In case any of these adverse effects worsen or continue, you should inform your doctor immediately. It is important to know that Clarithromycin is prescribed for you by your physician because they believe that the health benefits outweigh the side effects. In case you develop any adverse effects that you are not comfortable with however, you need to inform your doctor immediately. It is important to also mention that there are many people that use Biaxin who do not experience any serious side effects. In rare cases, Biaxin can also cause a severe intestinal symptom resulting from a type of resistant bacteria.
You should not use any medicaments to stop diarrhea while using Biaxin, except with the prescription of your doctor. You should also not take narcotic pain drug for any symptom of the medication because using a narcotic pain reliever can make the symptoms worsen. Do not use the drug for longer than prescribed to prevent having oral thrush or yeast infection. In the event that you notice white patches on your mouth, or an altering in your vaginal discharge, call your health care provider. Severe allergic reaction to this medication is not very common.
You should however seek for medical attention in case you develop any severe symptoms. It is important to mention that the list of side effects mentioned in this article is not exhaustive. You should therefore call your doctor if you experience any symptoms outside what is written here. Interaction with Other Drugs There are some other drugs that can interact with Biaxin. It is therefore very important that you inform your health care provider if you are currently using any medicine, or if you have just stopped using certain ones. Inform your physician of all medicament you take: Heart failure; Slow heartbeat; Family history of heart disease.
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