Headache along with dizziness, fast heartbeats, fainting, short breath and chest pain. Renal problems like little or no urine, swelling on feet and ankles, difficult or painful micturation, short breath and fatigue. Hearing problems Hepatic problems like abdominal pain, fatigue, nausea, loss of appetite, clay- colored stool, dark urine, and jaundice. Skin reactions along with fever, swelling on face or tongue, sore throat, skin pain, burning in eyes, purple or red rashes on skin, particularly on upper body as well as face. These rashes often result in blistering and peeling. Older adults who take Biaxin may have to face severe side- effects like life- threatening rapid heart rate.
If your infection is treated with a combination of drugs, use all medications as directed by your doctor. Read the instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. See also: Biaxin dosage information in more detail What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe stomach pain , nausea , vomiting , or diarrhea.
What should I avoid while taking Biaxin? Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Biaxin side effects Get emergency medical help if you have signs of an allergic reaction to Biaxin: Call your doctor at once if you have: If you've ever had heart problems, clarithromycin may cause a heart attack or stroke years after you've taken this medicine. Seek medical attention right away if you have chest pain spreading to your jaw or shoulder, trouble breathing, slurred speech, or sudden numbness or weakness on one side of your body.
Older adults may be more likely to have heart rhythm side effects, including a life-threatening fast heart rate. The more pills in a package, the lower the price for 1 pill! The price of the product includes the shipping rate 9. Buy Clarithromycin Online Clarithromycin is authorised in the world under the following brand names: Organs and Systems Cardiovascular QT interval prolongation and a ventricular dysrhythmia occurred in an HIV-positive 30-year-old man at the start of intravenous clarithromycin therapy 500 mg 12-hourly. Intravenous clarithromycin caused thrombophlebitis in four patients when it was given inappropriately as a rapid bolus injection instead of a short infusion; the manufacturers have received other reports of similar reactions, even with infusions, but the incidence seems to be considerably lower than with erythromycin.
In a prospective, non-randomized study, phlebitis occurred in 15 of 19 patients treated with intravenous erythromycin incidence rate of 0. Respiratory Bronchospasm with clarithromycin occurred in a 44-year-old woman who had no history of respiratory allergies but had had adverse drug reactions to general and regional anesthetics and to ceftriaxone. After the administration of a quarter of the therapeutic dose the patient had dyspnea, cough, and bronchospasm throughout the lung. This myasthenic syndrome resolved within 6 hours of withdrawal of clarithromycin and administration of pyridostigmine. The authors postulated that this adverse effect may have been the consequence of neuromuscular blockade, through inhibition of the presynaptic release of acetylcholine.
Sensory systems Topical clarithromycin can cause self-resolving corneal deposits. Ears Ototoxicity was attributed to clarithromycin in a 76-year-old man 4 days after he started to take clarithromycin for atypical pulmonary tuberculosis. When the clarithromycin was withdrawn his hearing improved subjectively, but it worsened again on re-exposure. Taste Abnormal taste developed in 17 of 175 patients treated with clarithromycin 250 mg bd for 10 days for community-acquired pneumonia , compared with 3 of 167 patients treated with sparfloxacin.
Psychological, psychiatric Two patients, a man aged 74 and a woman aged 56 years, developed delirium after taking clarithromycin. In both cases the psychosis resolved on withdrawal but recurred on rechallenge. In one case treatment with azithromycin was well tolerated. His symptoms resolved on withdrawal of all three drugs, and did not recur with erythromycin or when fluoxetine and nitrazepam were restarted in the absence of antibiotics. The symptoms may have been due to a direct effect of clarithromycin or else inhibition of hepatic cytochrome P450 metabolism, leading to fluoxetine toxicity. Clarithromycin occasionally causes hallucinations.
Visual hallucinations with marked anxiety and nervousness occurred after the second dose of oral clarithromycin 500 mg in a 32-year-old woman. Clarithromycin was withdrawn and the symptoms disappeared a few hours later. Visual hallucinations developed in a 56-year-old man with chronic renal insufficiency and underlying aluminium intoxication maintained on peritoneal dialysis 24 hours after he started to take clarithromycin 500 mg bd for a chest infection, and resolved completely 3 days after withdrawal. Hematologic Thrombotic thrombocytopenic purpura was reported in a 42-year-old man with no past medical history after he had just completed a 30-day course of clarithromycin 250 mg bd.
Gastrointestinal Erythromycin acts as a motilin receptor agonist. This mechanism may be at least partly responsible for the gastrointestinal adverse effects of macrolides. Clarithromycin may act on gastrointestinal motility in a similar way. In dogs, clarithromycin caused contractions and discomfort, as did erythromycin. In healthy volunteers, oral clarithromycin 250 mg bd caused a statistically significant increase in the number of postprandial antral contractions and antral motility. A single oral dose of clarithromycin 3000 mg resulted in severe abdominal pain within 1 hour of administration in two patients.
Based on observations made in dogs and rabbits, clarithromycin is significantly less potent than azithromycin and erythromycin as an agonist for stimulation of smooth muscle contraction. Therefore, a lower rate of gastrointestinal adverse events would be expected with clarithromycin. Pseudomembranous colitis is relatively rarely seen with macrolides, but has been reported with clarithromycin. Clarithromycin was also associated with cholestatic hepatitis. The pattern of liver enzyme abnormality was primarily cholestatic, and the patients were typically elderly all but one aged over 60 years , or of low weight. Only three patients were symptomatic, and the liver function abnormalities resolved on withdrawal.
Subsequent rechallenge was successful in four patients, unsuccessful in one, and not performed in four. There was some dispute as to whether toxicity was dose-related or not, but it is wise to recommend that elderly patients should receive an initial daily dose of 1 g in this disease setting. Although cholestatic hepatitis has been typically described in association with erythromycin, newer macro-lides are not totally free of this risk. A gradual increase in bilirubin and transaminases has been reported during treatment of a Mycobacterium chelonae infection with clarithromycin.
These alterations were quickly reversible after withdrawal, but re-appeared on re-exposure to clarithromycin 1 g.
Clarithromycin can cause phototoxicity. Side Effects See also Macrolide antibiotics Clarithromycin is a commonly used macrolide antibiotic and is a regular part of regimens for the eradication of Helicobacter pylori , often in combination with a nitromidazole antibiotic as well, in addition to a proton pump inhibitor. Comparative studies In a double-blind, multicenter trial in 328 patients with H. The rate of success and quality of life were similar in both groups. There were no serious adverse events. However, there were 12 withdrawals in the group given omeprazole and antibiotics and two in the group given omeprazole alone.
Diarrhea occurred in 63 patients in those given omeprazole and antibiotics and in ten patients given omeprazole alone. In another double-blind, placebo-controlled trial eradication of H. Treatment regimens for patients with a positive culture for MAC from a sterile site should include two or more drugs, including clarithromycin. In a prospective, single-blind, randomized study of a 7-day course of clarithromycin 7. Three subjects given erythromycin withdrew prematurely because of adverse events: Tetracyclines Clarithromycin 0. Eight patients did not complete the study owing to deviations from protocol or adverse effects.
Persistently negative cultures were found in 14 of the other patients. There were three cases of hepatic disturbances and three of ototoxicity, which required a reduction in clarithromycin dosage after a short interruption of treatment. I am experiencing the metallic Taste. How long does this last? Does it go away quickly when I stop taking the drug? Also the label says I should continue for one full week. But in the data I found on line there is no mention of continuing full term. So if I feel like it cured me, can I just stop? Dear Barry: The metallic taste is a common side effect with the antibiotic Biaxin. It will usually go away after you discontinue the medication.
In general you should always take an antibiotic until it is completed. For example, if your doctor prescribed it for 10 days, take it for the entire time. Even though you may feel good, the longer duration of therapy will insure that you do not get a recurrence of your infection. Drug-Drug Interactions Antifungal imidazoles In three patients with pulmonary MAC and aspergillosis infections, itraconazole was suggested to increase the plasma concentration of clarithromycin as well as the clarithromycin: This effect may have been due to inhibition of CYP3A4 by itraconazole. Antihistamines Toxic effects of terfenadine and astemizole have been reported in patients taking concomitant macrolides, especially clarithromycin, typically resulting in prolongation of the QT interval and cardiac dysrhythmias torsade de pointes.
Cisapride Cisapride can prolong the QT interval, with a risk of ventricular dysrhythmias. Clarithromycin increases serum concentrations of cisapride. This potentially dangerous interaction can result in QT interval prolongation and dysrhythmias such as torsade de pointes. Torsade de pointes occurred in a 77-year-old woman taking cisapride and clarithromycin. Warnings have been issued by the manufacturers to avoid concomitant administration. Colchicine Fatal colchicine intoxication occurred in a 67-year-old man who had taken clarithromycin 500 mg bd for 4 days.
Clarithromycin may have inhibited colchicine metabolism and caused a rise in colchicine concentration. Digoxin Clarithromycin has been reported to cause digoxin toxicity. Two different mechanisms are involved, inhibition of the renal excretion of digoxin and alteration of intestinal flora, which reduces the presystemic hydrolysis of digoxin. A 70-year-old woman taking digoxin for atrial fibrillation developed nausea, vomiting, and dizziness 2 days after starting to take clarithromycin. Her serum digoxin concentration was 3. Hearing problems Hepatic problems like abdominal pain, fatigue, nausea, loss of appetite, clay- colored stool, dark urine, and jaundice.
Skin reactions along with fever, swelling on face or tongue, sore throat, skin pain, burning in eyes, purple or red rashes on skin, particularly on upper body as well as face. These rashes often result in blistering and peeling. Older adults who take Biaxin may have to face severe side- effects like life- threatening rapid heart rate. Fever, body ache, symptoms of flu, coughing and swollen glands. Bad taste in mouth. In the case of changing the medicine form, consult your doctor as the change of form can also change the composition of the medicine a bit.
Direction for use If you are taking the oral suspension of the medicine then you should not shake the bottle but the turn is upside down three times before open the bottle to get the medicine mixed well. Use the measuring cup to get the exact amount of medicine In the case of using the extended-release tablets do not chew or crush them but have the solute in water first and have it in one go. Do not take the medicine in a larger amount or for a longer period. Make sure to take medicine on same time every day to ensure the best results and do not skip the medicine.
Delays or skipping the medicine can immune the bacteria and extent the medication tenure as well. Do not refrigerate the Biaxin, in fact, keep it at dry and at room temperature. Keep the liquid bottle of Biaxin close tightly and away from direct sunlight.
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As all the other antibiotics Biaxin is also a prescription medicine and it should be used according to the prescription by the doctor and method mention on the label of the medicine. When you consult your doctor for the treatment and get the prescription of Biaxin, it is customized for you only. Biaxin belongs to the class of macrolide antibiotics. Biaxin fights bacteria in your body. Biaxin is used to treat many types of bacterial infections such as bronchitis, pneumonia, sinusitis, tonsillitis, skin infections, and bacterial stomach ulcers. Biaxin may be used for purposes other than those described in this manual. Contraindications of Biaxin. Biaxin is strictly contraindicated in the patients who suffer from serious life- threatening heart rhythm disorders, hypokalaemia (lower levels of potassium in the blood), history of Long QT syndrome, a history of jaundice or hepatic problems that occurred by the use of Biaxin, renal or hepatic disease and if you are consuming colchicines.